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M9470140.TXT
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1994-07-02
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Document 0140
DOCN M9470140
TI Oxygen radical release by neutrophils of HIV-infected patients.
DT 9409
AU Jarstrand C; Akerlund B; Department for Clinical Microbiology, Huddinge
University; Hospital, Sweden.
SO Chem Biol Interact. 1994 Jun;91(2-3):141-6. Unique Identifier : AIDSLINE
MED/94251840
AB Neutrophils from asymptomatic HIV-infected patients have an increased
Nitroblue tetrazolium (NBT) reduction, that is an increased production
of oxygen radicals. Plasma from these patients can activate normal
neutrophils to an increased NBT-reduction and the neutrophil activating
factor thus seems to be mainly plasma bound. Further, the patients also
have increased levels of plasma malondialdehyde and thus an increased
lipid peroxidation. Plasma cysteine levels are low, a sign of increased
consumption of antioxidants. Treatment of the asymptomatic HIV-infected
patients with N-acetylcysteine corrected the plasma cysteine levels and
had some beneficial effects, but did not inhibit the increased radical
production by the neutrophils.
DE Acetylcysteine/*THERAPEUTIC USE Acquired Immunodeficiency
Syndrome/BLOOD Adult AIDS-Related Complex/BLOOD Cysteine/BLOOD
Female Free Radicals Human HIV Infections/*BLOOD/DRUG THERAPY Male
Neutrophils/*METABOLISM Oxidation-Reduction Randomized Controlled
Trials Superoxides/*BLOOD JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).